Headaches are a common cause
of suffering, but all headaches
are not created equal. The
main challenge to affording
relief from various forms
of "cephalgia," or "head
pain," is categorizing a
headache by type, and then
proceeding with the therapy
most likely to help.
The
International Headache Society’s
landmark work on headache
classification has allowed
important advances in headache
study, but is somewhat awkward
to use in clinical practice.
One practical approach is
to first distinguish "urgent"
headaches (those that may
be life-threatening) from
others that may be less
urgent, if no less distressing.
Identifying "special" headaches
(those that may only benefit
from specific therapy) is
the next step. Finally,
if neither of these classifications
fit, treatment of tension
or migraine headache (the
most common) is in order.
Urgent Headaches

Urgent headaches may
be immediately life-threatening,
and should be treated promptly.
Subarachnoid hemorrhage
("aneurysm")
Patients typically describe
a headache related to a
leaking aneurysm as a sudden,
"thunderclap" headache,
often the "worst headache
of my life" (an "aneurysm"
is a swelling of a blood
vessel in the brain). After
this sudden onset, the pain
may persist at a high or
low intensity for days.
Abnormal neurological symptoms
may occur, including brief
loss of consciousness at
the onset of the headache,
a stiff neck, or eye movement
abnormalities.
Such a headache mandates
prompt evaluation by a physician,
since a missed aneurysmal
leak can result in a catastrophic
stroke or death. Evaluation
typically takes place in
an emergency department,
and includes a brain computed
tomography (CT) scan. A
spinal tap (looking for
leaked red blood cells)
may be necessary to completely
rule out the diagnosis.
An MRI may be useful, but
typically requires neurology
or neurosurgery consultation.
The definitive treatment
for subarachnoid bleeding
is surgery, although calcium
channel blocking drugs (nimodipine)
may limit damage.
Temporal (giant cell)
arteritis
Patients with temporal
arteritis (TA, an inflammatory
process involving the walls
of medium-sized arteries)
are usually over age 50.
Its symptoms are newly experienced
localized headache, scalp
tenderness and diminished
pulse over the temple area,
fevers, and aches. An unusual
symptom highly suggestive
of TA is "jaw claudication,"
or cramping of the jaws
while chewing.
Blindness (due to involvement
of the ophthalmic artery)
is a frequent complication,
and may be prevented with
prompt therapy. Blood tests
reveal intense inflammation
(with a high "ESR" test),
and definitive diagnosis
is made by finding inflammation
on a biopsy specimen taken
from the temporal artery.
Treatment consists of
prompt therapy with high-dose
corticosteroids (such as
prednisone), which should
be instituted if the syndrome
is suspected (even before
definitive biopsy results
return.
Bacterial meningitis
Acute bacterial meningitis
is a virulent infection,
and is typically manifest
by an ill-appearance, fever,
headache, stiff neck, and
photophobia (avoidance of
bright light). A rash may
be present some forms.
Diagnosis consists of
a spinal tap showing white
blood cells, chemical tests,
and bacteriology studies.
Treatment requires prompt
antibiotic therapy.
CT scans and MRIs
While a "negative" CT
of the brain is reassuring,
the cost of imaging every
person with headache is
prohibitive (up to $3 billion/year
in the US). Moreover, a
CT scan will find an identifiable
cause of headache (blood,
tumor) in no more than 0.5
to 2.5% of patients, and
most of these patients have
abnormal clinical findings.
The Table lists indications
for CT scan or MRI for headache.
- Findings Suggesting
Need For Neuroimaging
- "Worst headache
of my life"
- Headache onset after
exertion
- Decreased alertness
- Stiff neck
- Abnormal neurological
findings
- Decline during observation
- New headache lasting
> 2 months in patient
40-60 years old
Special Headaches
Brain tumor
Though a fear for many
headache sufferers, brain
tumors are uncommon. Indeed,
fewer than 20% of patients
with brain tumors experience
only headache as a symptom
(the most frequent symptom
is seizure and/or neurological
abnormality on exam). Waking
with a headache is said
to be an important sign
of a tumor-related headache,
although this occurs frequently
in chronic headaches.

Treatment is determined
by consultation with a neurosurgeon.
Cluster Headache
Cluster headache commonly
affects young- to middle-aged
men. It is of short duration
(30-90 minutes) and causes
headache behind one eye,
with eye redness, tearing,
and nasal stuffiness on
the involved side. Headaches
are clustered over time
(often separated by weeks
to months); in times of
headache activity, headaches
may occur up to 6 times
a day, often causing insomnia.
Diagnosis is based on
its classic presentation.
Treatment includes high-dose
anti-inflammatory medications
(ibuprofen, others). For
unknown reasons, over half
get relief from breathing
100% oxygen by face mask.
Coital Headache
Coital headache occurs
around the time of intercourse,
and lasts from minutes to
hours, and may be indistinguishable
from subarachnoid hemorrhage.
Diagnosis may require
CT and spinal tap to rule
out subarachnoid hemorrhage.
Sinus Headache
Typically occurring in
conjunction with upper respiratory
tract infection or allergic
rhinitis/sinusitis, sinus
headache is usually dull
and constant, worse when
bending forward, and may
be associated with colored
nasal discharge.
Diagnosis may be made
clinically, by x-rays, or
on CT.
Treatment is based on
cause (antibiotics if bacterial,
antihistamines/decongestants/intranasal
steroids if allergic), and
are supplemented by interventions
to promote drainage (brief
course of nasal spray, intranasal
saline mist).
Eye Strain Headache
This headache is associated
with prolonged reading or
staring at a computer screen
(but not with astigmatism
or refractive errors).
Hormonal Headache
While temporally related
to menstrual cycle, menopausal
flushing, or hormone use
(oral contraceptives), this
headache has no distinguishing
features otherwise.
Pain tends to diminish
cyclically, or after menopause
is completed (but only in
1/3 who develop menopausal
headaches), or after hormone
discontinuation.
Benign Intracranial
Hypertension
Also known as "pseudotumor
cerebri," this syndrome
typically affects young,
overweight women on certain
medications (oral contraceptives,
tetracycline, certain steroids,
or vitamin A). The headache
itself is nondescript, but
exam findings include swelling
of the optic nerve, which
usually raises the specter
of brain tumor.
CT scan looks essentially
normal, and a spinal tap
reveals high pressure.
Therapy includes corticosteroids.
Post-Traumatic Headache
(Concussion)
"Concussion" is defined
as loss of consciousness
associated with head injury.
Symptoms include headache,
dizziness, and confusion;
long-term symptoms are headache,
irritability, fatigue, anxiety,
insomnia, memory disturbance,
and impaired concentration
may persist for up to 18
months.
A CT scan is typically
normal.
Treatment involves support
with mild analgesia and
reassurance.
Migraine With Aura (Classic
Migraine)
A typical headache is
heralded by an aura (blinking
lights with partial vision
loss, then sight restoration)
followed in 25 to 60 minutes
by a throbbing, unilateral
headache associated with
nausea, vomiting, and photophobia
lasting 6-8 hours.
Abortive treatment includes
non-steroidal anti-inflammatory
medications, anti-nausea
medications, ergot derivatives,
and other agents; preventive
treatment involves various
agents.

Common Headaches
While these headaches
may have somewhat different
causes, their manifestations
(and treatment) are similar.
Both may be triggered by
stress.
Migraine Without Aura
(Common Migraine)
Migraine headache tends
to be throbbing and one-sided
(typically over the temporal
area), and precipitated
by certain foods, strong
smells, or the menstrual
cycle (the ratio of female
to male sufferers is 3 to
1). The time of day of onset
varies.
Diagnosis is based on
symptoms and lack of neurological
abnormalities.
Treatment is the same
as above.
Tension Headache
Often located in a both-sided
"hatband" and neck distribution,
tension headache is constant,
precipitated by stress,
has no associated symptoms,
and usually occurs later
in the day; female to male
ratio is 1 to 1.

Diagnosis is by clinical
characteristics.
Treatment involves a
step-wise approach, beginning
with over-the-counter non-steroidal
medications or acetaminophen,
followed by prescription-strength
doses when necessary. Worse
headaches may require migraine-type
medications, such as Midrin
(isometheptene, dichloralphenazone,
and acetaminophen). Medications
containing caffeine or butalbital
are sometimes used (though
risk of rebound headache
increases). Prophylactic
treatments similar to those
used for migraine may be
useful.